Setup 
Align the doubles to anywhere on the field
1. Check to see which gaps the defensive tackles are lined up in 

Reads
1. If no defender is in the gap just right of the center - quick snap and run play

2. If there is a defender in the the gap just right of center, mostly likely it will allow for the outside defender to be one that is trapped by the guard. In this case, you want to make sure you slow down your RB when you get the ball and make sure you are able to cut behind your guard before taking it upfield

3. If the defense is in a pinched alignment where both gaps to the left and right of the center has defenders, you want to look for a cut back lane towards the side in which my RB started from.